Neurology

Contains research objectives and reports on three research projects.Office of Naval Research (Nonr-609(39))U. S. Air Force (AF33(616)-7282)Army Chemical Corps (DA-18-108-405-Cml-942)U.S. Public Health Service (B-3055)U. S. Air Force (AF49(638)-1130)U.S. Public Health Service (B-3090

Neurology

Contains reports on five research projects.United States Navy, Office of Naval Research (Nonr-609(39))United States Public Health Service (B-3055, B-3090)Unites States Air Force (Contract AF33(616)-7282)Unites States Air Force (Contract AF-33(616)-7588, Project: 61(8-7232); Task 71784))United States Army Chemical Corps (DA-18-108-405-Cml-942

Transits across a Cyclopentadienyl: Organic and Organometallic Haptotropic Shifts

references cited therein. (13) Electron acceptors which are also conjugated with the alkene r system will polarize the HOMO in the same directions as, but to a smaller extent than, Inductive acceptors.8 (14) There has been a suggestion that Me is an acceptor relative to H when attached to an sp3 carbon [C. A. Grob, Angew. Chem. lnt. Ed. Engl., 15, 569 (1976), and references cited therein]. The product ratio discussed here reflect this, but the IP changes do not. A subtle role of solvent may be involved. (15) J. Bastideand J. P. Maier, Chem. Phys., 12, 144 (1976 Li+, CUR+), the e component of which greatly stabilizes the most symmetrical q5 coordination. The lower the energy of the e acceptor set and the better the overlap with its Cp counterpart, the more are q2 and q5 stabilized relative to 7'. In the case of XH3+ (X = C, Si, Ge, Sn) an e acceptor orbital moves to lower energy as one proceeds down the group, and this is responsible for the decreasing barrier for sigmatropic shifts in CpXH3. The XH2 case, which yields a number of interesting collapse structures, is analyzed in detail for X, a main group center. Contrast the interaction of a cyclopentadienide anion and a proton with the interaction of the same anion and a Mn(CO)3+ fragment. Both result in stable molecules: cyclopentadiene (1) and V~-C~M~( C O )~ (2). But what a difference in the equilibrium geometries of these end products of the interaction! If we focus our attention on the cyclopentadienide site where the interacting partner settles down, then the proton chooses a position near to one carbon of the ring, but the Mn(C0)3+ fragment sits directly over the center of the ring. The ramifications of this differential are the concern of this paper. We will examine the interaction of a cyclopentadienide (CsHs-, Cp) ion with an interacting group X, X = H+, CH3+, SiR3+, Mn(C0)3+, CH22f, CH2. The result will consist of some conclusions concerning the equilibrium geometry of CpX as well as the relative energetics of the various haptotropic reactions of this Consider the passage of the interacting group X across the face of a Cp molecule, moving as indicated in 3 in a plane parallel to the Cp ring. Let the distance d be a separation at which there is sizable interaction between the frontier orbitals of X and the Cp a system. For a surface so constrained the asymmetric unit that need be calculated consists of the shaded area in 4, and two of the three boundaries of that area are contained in a transit along a line shown in projection in 5. Mirror symmetry is maintained at all points. The numbers nq shown along that line are convenient labels invoking a connection to the inorganic 7" notation* for denoting an approximate coordination geometry. In order to avoid confusion with structure numbers and ring carbon numbers, we have labeled the various sites along the transit line as 17, 217, . . . , 57. The site labeled 17, or some geometry near it, corresponds to or simple u interaction, such as we have in the collapse product cyclopentadiene. The 7IS site 57 is where one better come up with maximum stabilization for X = Mn(C0)3+. The site labeled 27 positions X over the center of a bond, and obviously will describe the important transition state region for a sigmatropic shift of a system like cyclopentadiene. 37 and 47 are not so easily defined. Experimentally, slippage of Cp rings from q5 coordination is often observed and q3 or q4 coordination may or may not be invoked. Somewhat arbitrarily we define 317 at the intersection of the transit line with the line joining C-2 and C-5 projected on the transit plane. The tetrahapto coordination site is most ambiguous (it could be near 37 or near 57), and SO we will not label any position as such. The analysis will consist of an inspection of interaction diagrams for the orbitals of Cp and X, as the ligand X and its position along the transit are varied. The qualitative arguments based on symmetry and overlap are supported by extended Huckel calculations whose details are given in the Appendix. The reader should be aware that this is an approximate metho

Neurology

Contains reports on nineteen research projects.United States Public Health Service (B-3055-3, B-3090-3, 38101-22)United States Navy, Office of Naval Research (Contract Nonr-1841(70))Unites States Air Force (AF33(616)-7588, AFAOSR 155-63)United States Army Chemical Corps (DA-18-108-405-Cml-942)National Institutes of Health (Grant MH-04734-03)National Aeronautics and Space Administration (Grant NsG-496

Neurology

Contains reports on eight research projects.United States Air Force (AF33(616)-7588, AF49(638)-1130)National Science Foundation (Grant G-16526)United States Army Chemical Corps (DA-18-108-405-Cml-942)United States Public Health Service (B-3055, B-3090)United States Navy, Office of Naval Research (Contract Nonr-1841(70)

Neurology

Contains reports on eleven research projects.U.S. Air Force (AF49(638)-1130)Army Chemical Corps (DA-18-108-405-Cml-942)U.S. Public Health Service (B-3055)National Science Foundation (Grant G-16526)U.S. Public Health Service (B-3090)U.S. Air Force (AF33(616)-7588)Office of Naval Research (Nonr-1841(70)

Description of the two-nucleon system on the basis of the Bargmann representation of the S matrix

For the effective-range function $k\cot \delta$, a pole approximation that involves a small number of parameters is derived on the basis of the Bargmann representation of the $S$ matrix. The parameters of this representation, which have a clear physical meaning, are related to the parameters of the Bargmann $S$ matrix by simple equations. By using a polynomial least-squares fit to the function $k\cot \delta$ at low energies, the triplet low-energy parameters of neutron-proton scattering are obtained for the latest experimental data of Arndt et al. on phase shifts. The results are $a_{t}=5.4030$fm, $r_{t}=1.7494$fm, and $v_{2}=0.163$fm$^{3}$. With allowance for the values found for the low-energy scattering parameters and for the pole parameter, the pole approximation of the function $k\cot \delta$ provides an excellent description of the triplet phase shift for neutron-proton scattering over a wide energy range ($T_{\text{lab}}\lesssim 1000$MeV), substantially improving the description at low energies as well. For the experimental phase shifts of Arndt et al., the triplet shape parameters $v_{n}$ of the effective-range expansion are obtained by using the pole approximation. The description of the phase shift by means of the effective-range expansion featuring values found for the low-energy scattering parameters proves to be fairly accurate over a broad energy region extending to energy values approximately equal to the energy at which this phase shift changes sign, this being indicative of a high accuracy and a considerable value of the effective-range expansion in describing experimental data on nucleon-nucleon scattering. The properties of the deuteron that were calculated by using various approximations of the effective-range function comply well with their experimental values.Comment: 39 pages, 3 figure

Challenges and opportunities for converting renal cell carcinoma into a chronic disease with targeted therapies

Optimum efficacy is the primary goal for any cancer therapy, and entails controlling tumour growth and prolonging survival as far as possible. The prognosis for patients with metastatic renal cell carcinoma (mRCC) has greatly improved with the introduction of targeted therapies. This review examines the development and efficacy of targeted agents for the management of mRCC, the challenges offered by their rapid emergence, and discusses how mRCC treatment may evolve in the future. Improvements in progression-free survival and overall survival rates, observed with targeted agents, indicate that it may now be possible to change mRCC from a rapidly fatal and largely untreatable condition into a chronic disease. The major challenges to further advances in targeted therapy for mRCC include overcoming drug resistance, identifying the most effective sequence or combination of targeted agents, optimising clinical trial design and managing the cost of treatment

Diversity Partitioning of Stony Corals Across Multiple Spatial Scales Around Zanzibar Island, Tanzania

The coral reefs of Zanzibar Island (Unguja, Tanzania) encompass a considerable proportion of the global coral-reef diversity and are representative of the western Indian Ocean region. Unfortunately, these reefs have been recently subjected to local and regional disturbances. The objectives of this study were to determine whether there are potentially non-random processes forcing the observed coral diversity patterns, and highlight where and at which spatial scales these processes might be most influential.A hierarchical (nested) sampling design was employed across three spatial scales, ranging from transects (<or=20 m), stations (<100 m), to sites (<1000 m), to examine coral diversity patterns. Two of the four sites, Chumbe and Mnemba, were located within Marine Protected Areas (MPAs), while the other two sites, Changuu and Bawe, were not protected. Additive partitioning of coral diversity was used to separate regional (total) diversity (gamma) into local alpha diversity and among-sample beta diversity components. Individual-based null models were used to identify deviations from random distribution across the three spatial scales. We found that Chumbe and Mnemba had similar diversity components to those predicted by the null models. However, the diversity at Changuu and Bawe was lower than expected at all three spatial scales tested. Consequently, the relative contribution of the among-site diversity component was significantly greater than expected. Applying partitioning analysis for each site separately revealed that the within-transect diversity component in Changuu was significantly lower than the null expectation.The non-random outcome of the partitioning analyses helped to identify the among-sites scale (i.e., 10's of kilometers) and the within-transects scale (i.e., a few meters; especially at Changuu) as spatial boundaries within which to examine the processes that may interact and disproportionately differentiate coral diversity. In light of coral community compositions and diversity patterns we strongly recommend that Bawe be declared a MPA

Measurement of the BB Meson Differential Cross Section, dσ/dpTd\sigma/dp_T, in ppˉp\bar{p} Collisions at s=1.8\sqrt{s} = 1.8 TeV

This paper presents the first direct measurement of the $B$ meson differential cross section, $d\sigma/dp_T$, in $p\bar{p}$ collisions at $\sqrt{s}=1.8$ TeV using a sample of $19.3 \pm 0.7$ pb$^{-1}$ accumulated by the Collider Detector at Fermilab (CDF). The cross section is measured in the central rapidity region $|y| 6.0$ GeV/$c$ by fully reconstructing the $B$ meson decays $B^{+}\to J/\psi K^{+}$ and $B^{0}\to J/\psi K^{*0}(892)$, where $J/\psi \to \mu^+\mu^-$ and $K^{*0} \to K^+ \pi^-$. A comparison is made to the theoretical QCD prediction calculated at next-to-leading order.Comment: 14 pages. Submitted to Phys. Rev. Lett. The postscript file is at http://www-cdf.fnal.gov/physics/pub95/cdf2893_bexcl_xsection.p